Concepedia

Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Superrelaxed Myosin

Tatsuro Hitsumoto, Osamu Tsukamoto, Ken Matsuoka, Junjun Li, Li Liu, Yuki Kuramoto, Shuichiro Higo, Shou Ogawa, Noboru Fujino, Shohei Yoshida,

Circulation · 2023 · 28 citations · 38 references

DOI Full text

Open access

Abstract

cMLCK dysregulation contributes to the development of cardiac systolic dysfunction in humans. Our strategy to restore cMLCK activity could form the basis of a novel myotropic therapy for advanced systolic heart failure.

References

38

Measurement of cardiac function using pressure–volume conductance catheter technique in mice and rats

Pál Pacher, Takahiro Nagayama, Partha Mukhopadhyay et al. · Nature Protocols · 2008 · 713 citations · Full text

Cardiac Function, Health Sciences, Cardiac Physiology +10

Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure

John R. Teerlink, Rafael Díaz, G. Michael Felker et al. · New England Journal of Medicine · 2020 · 625 citations · Full text

Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure

Fady I. Malik, James J. Hartman, Kathleen A. Elias et al. · Science · 2011 · 590 citations · Full text

Cardiac Muscle, Heart Failure, Cardiovascular Pharmacology +20

ssODN-mediated knock-in with CRISPR-Cas for large genomic regions in zygotes

Kazuto Yoshimi, Yayoi Kunihiro, Takehito Kaneko et al. · Nature Communications · 2016 · 353 citations · Full text

Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy

Christopher N. Toepfer, Amanda C. Garfinkel, Gabriela Venturini et al. · Circulation · 2020 · 308 citations · Full text