International Journal of Clinical Practice · 2002 · 35 citations · 66 references
PharmacyPharmacotherapyPsychiatryNeuropharmacologyPsychopharmacologyStroke RehabilitationAntidepressant PharmacotherapyAntidepressant TherapyDepression ManagementDepression PharmacotherapyStrokeStroke PharmacotherapyAntidepressant MedicationsCognitive IncapacityDepression PathophysiologyDepression-associated Cognitive ImpairmentPost-stroke Depression ManagementPost-stroke RecoveryPost-stroke Rehabilitation
SUMMARY Stroke is considered mainly as a physical disability, and stroke‐related depression is under‐recognised Cognitive, language and functional impairment complicates the recognition of post‐stroke depression. The pathophysiology of post‐stroke depression is poorly understood, but several risk factors have been identified. Depression following stroke can impede recovery and rehabilitation and is associated with higher mortality. Randomised trials show that antidepressants, especially selective serotonin uptake inhibitors, are effective in the treatment of this condition. Despite the evidence available, a large number of patients remain undertreated. Early identification and treatment can reduce the functional impairment and mortality related to post‐stroke depression.
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Martín Keller, James P. McCullough, Daniel N. Klein et al. · New England Journal of Medicine · 2000 · 1.3K citations · Full text
Major depression in stroke patients. A 3-year longitudinal study.
Maria Åström, Rolf Adolfsson, Kjell Asplund · Stroke · 1993 · 695 citations · Full text
Medicine, Neurology, Psychiatry +17
NORTRIPTYLINE TREATMENT OF POST-STROKE DEPRESSION: A DOUBLE-BLIND STUDY
JohnR Lipsey, GodfreyD. Pearlson, RobertG Robinson et al. · The Lancet · 1984 · 541 citations