Clinical and Translational Discovery · 2023 · 17 citations · 111 references
MedicineOncologyUrologyGenitourinary OncologyMolecular OncologyUrologic OncologyBiomarkers In Genitourinary CancerBiomarkers In Urologic OncologyBladder CancerCancer BiomarkersCancer Molecular DiagnosticsLiquid BiopsyBladder Cancer DiagnosisCircular RnasEarly ScreeningLiquid Biopsy BiomarkersTransfer Rna-derived FragmentsUrine BiomarkersUrine-based Cancer DetectionUrine-based Diagnostics
Abstract Urine‐based liquid biopsy has emerged as a non‐invasive and effective tool for early screening and diagnosis of bladder cancer. This review provides a comprehensive overview of the current urine‐based biomarkers and methods for the detection and monitoring of bladder cancer. We focus on biomarkers including tumour DNAs, proteins, microbiome, tumour RNAs, long non‐coding RNAs, transfer RNA‐derived fragments, messenger RNAs, microRNAs, circular RNAs, exosomes and extrachromosomal circular DNA.
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Circular RNAs are a large class of animal RNAs with regulatory potency
Sebastian Memczak, Marvin Jens, Antigoni Elefsinioti et al. · Nature · 2013 · 8.5K citations
Xi Chen, Yi Ba, Lijia Ma et al. · Cell Research · 2008 · 4.6K citations
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
Mitchell Guttman, Ido Amit, Manuel Garber et al. · Nature · 2009 · 4.2K citations · Full text
Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden
Zachary R. Chalmers, Caitlin Connelly, David Fabrizio et al. · Genome Medicine · 2017 · 3.7K citations · Full text
Medicine, Cancer Biology, Oncology +17
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Gang Chen, Alexander C. Huang, Wei Zhang et al. · Nature · 2018 · 2.8K citations · Full text
Life Sciences, Immunology, Oncology +14