Concepedia

Publication | Open Access

Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression

DOIFull Paper Access

34

Citations

54

References

2023

Year

Janine M. DeBlasi, Aimee Falzone, Samantha Caldwell, Nicolas Prieto-Farigua, Justin R. Prigge, Edward E. Schmidt, Iok In Christine Chio, Florian A. Karreth, Gina M. DeNicola
Cancer Research

Abstract

Stabilization of the transcription factor NRF2 promotes oncogene-driven tumor initiation but blocks tumor progression, indicating distinct, threshold-dependent effects of the KEAP1/NRF2 pathway in different stages of lung tumorigenesis.

References

YearCitations

Page 1