Azidobenziodazolones as Azido Sources for the Enantioselective Copper-Catalyzed Azidation of <i>N</i>-Unprotected 3-Trifluoromethylated Oxindoles

Abstract

Both azido (N₃) and trifluoromethyl (CF₃) groups are key moieties of numerous valuable molecules that are extensively applied in drug discovery, chemical biology, and synthetic chemistry. However, the asymmetric construction of chiral quaternary stereocenters bearing both N₃ and CF₃ groups is still unexplored. Herein, we report a kind of bench-stable and easily adjustable benziodazolone-based azidating reagents. These reagents were used to achieve an enantioselective copper-catalyzed azidation of <i>N</i>-unprotected 3-trifluoromethylated oxindoles to provide diverse enantioenriched 3-N₃-3-CF₃ oxindoles.