Control of human pancreatic beta cell kinome by glucagon‐like peptide‐1 receptor biased agonism

Abstract

The results from this study suggest that differentially biased exendin-phe1 and exendin-asp3 can modulate distinct kinase interaction networks. Further understanding of these mechanisms will have important implications for the selection of appropriate anti-type 2 diabetes therapies with optimized downstream kinomic profiles.