Genome-scale CRISPR screen reveals neddylation to contribute to cisplatin resistance of testicular germ cell tumours - Concepedia

Concepedia

Publication | Open Access

Genome-scale CRISPR screen reveals neddylation to contribute to cisplatin resistance of testicular germ cell tumours

DOI Full Paper Access

22

Citations

38

References

2023

Year

Kai Funke, Ulf Einsfelder, Aylin Hansen, Lena Arévalo, Simon Schneider, Daniel Nettersheim, Valentin Stein, Hubert Schorle

British Journal of Cancer

Abstract

We identified overactivation of neddylation as a factor for cisplatin resistance in TGCTs and highlighted the additive effect of NAE1 inhibition by MLN4924 in combination with cisplatin as a novel treatment option for TGCTs.

References

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