Derivation of Benzothiadiazine‐1,1‐dioxide Scaffolds via Transition Metal‐Catalyzed C—H Activation/Annulation

Abstract

Comprehensive Summary Benzothiadiazine‐1,1‐dioxide scaffold is bioactive framework with wild utility and applications. Synthesis of benzothiadiazine‐fused isoquinoline derivatives and spiro benzothiadiazine derivatives through transition metal‐catalyzed C—H activation/annulation was reported. 3‐Phenyl‐2 H ‐benzothiadiazine‐1,1‐dioxide was used as the reaction substrate, and vinylene carbonate and 4‐diazopyrazolone were used as the coupling reagents, respectively. This strategy provides straightforward access to complex N ‐heterocycles in a highly efficient and simple manner.