LCZ696 (sacubitril/valsartan) inhibits pulmonary hypertension induced right ventricular remodeling by targeting pyruvate dehydrogenase kinase 4 - Concepedia

Concepedia

Publication | Open Access

LCZ696 (sacubitril/valsartan) inhibits pulmonary hypertension induced right ventricular remodeling by targeting pyruvate dehydrogenase kinase 4

DOI Full Paper Access

12

Citations

47

References

2023

Year

Mengjia Shen, Cankun Zheng, Lu Chen, Mingjue Li, Xiaoxia Huang, Mingyuan He, Chi-Yu Liu, Hairuo Lin, Wangjun Liao, Jianping Bin,

Biomedicine & Pharmacotherapy

Abstract

Pdk4 is a common therapeutic target for pressure overload-induced left ventricular and RV remodeling, and LCZ696 attenuates RV remodeling by downregulating Pdk4 and inhibiting PDK4/p-GSK3β signal.

References

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