Impaired Reorganization of Centrosome Structure Underlies Human Infantile Dilated Cardiomyopathy

Abstract

This study is the first to demonstrate a case of human disease caused by a defect in centrosome reduction. We also uncovered a novel role for <i>RTTN</i> in perinatal cardiac development and identified a potential therapeutic strategy for centrosome-related iDCM. Future study aimed at identifying variants in centrosome components may uncover additional contributors to human cardiac disease.