Periodontitis exacerbates atherosclerosis through <i>Fusobacterium nucleatum</i>-promoted hepatic glycolysis and lipogenesis

Abstract

PD exacerbates atherosclerosis and impairs lipid metabolism in mice, which may be mediated by F. nucleatum-promoted glycolysis and lipogenesis through PI3K/Akt/mTOR signalling in hepatocytes. Treatment of PD and specific targeting of F. nucleatum are promising strategies to improve therapeutic effectiveness of hyperlipidaemia and atherosclerosis.