CAPN1 (Calpain1)-Dependent Cleavage of STIM1 (Stromal Interaction Molecule 1) Results in an Enhanced SOCE (Store-Operated Calcium Entry) in Human Neonatal Platelets - Concepedia

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CAPN1 (Calpain1)-Dependent Cleavage of STIM1 (Stromal Interaction Molecule 1) Results in an Enhanced SOCE (Store-Operated Calcium Entry) in Human Neonatal Platelets

DOI Full Paper Access

11

Citations

52

References

2023

Year

Alejandro Berna‐Erro, Girish Ramesh, Elena Crespo Delgado, Antonio J. Corbacho, Francisca Ferrer‐Marín, Raúl Teruel, María P. Granados, Juan A. Rosado, Pedro C. Redondo

Arteriosclerosis Thrombosis and Vascular Biology

Abstract

CAPN1 may cleave STIM1 in neonatal platelets, hence, impairing SARAF coupling after SOCE activation. s-STIM1 may avoid slow Ca<sup>2+</sup>-dependent inactivation and, subsequently, results in an enhanced TG-evoked SOCE as observed in neonatal platelets.

References

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