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Publication | Open Access

P2RX7 signaling drives the differentiation of Th1 cells through metabolic reprogramming for aerobic glycolysis

DOIFull Paper Access

10

Citations

36

References

2023

Year

Érika Machado de Salles, Paulo Lisboa Raeder, Cláudia Blanes Angeli, Verônica Feijoli Santiago, Cristiane Naffah de Souza, Theresa Ramalho, Niels Olsen Saraiva Câmara, Giuseppe Palmisano, José María Álvarez, Maria Regina D’Império Lima
Frontiers in Immunology

Abstract

These data demonstrate that P2RX7-mediated metabolic reprograming for aerobic glycolysis is a key event for Th1 differentiation and suggest that ATP synthase inhibition is a downstream effect of P2RX7 signaling that potentiates the Th1 response.

References

YearCitations

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