Microglia–neuron interactions promote chronic itch via the <scp>NLRP3‐IL‐1β‐GRPR</scp> axis

Abstract

Our findings reveal a previously unknown mechanism in which microglia enhances the activation of GRPR⁺ neurons through the NLRP3/caspase-1/IL-1β/IL1R1 axis. These results will provide new insights into the pathophysiology of pruritus and novel therapeutic strategies for patients with chronic itch.