A Randomized Crossover Study Using Yohimbine and Isoxsuprine Versus Pentoxifylline in the Management of Vasculogenic Impotence

Abstract

No AccessJournal of UrologyClinical Urology: Original Article1 Jan 1996A Randomized Crossover Study Using Yohimbine and Isoxsuprine Versus Pentoxifylline in the Management of Vasculogenic Impotence L. Dean Knoll, Ralph C. Benson, David L. Bilhartz, Peter J. Minich, and William L. Furlow L. Dean KnollL. Dean Knoll More articles by this author , Ralph C. BensonRalph C. Benson More articles by this author , David L. BilhartzDavid L. Bilhartz More articles by this author , Peter J. MinichPeter J. Minich More articles by this author , and William L. FurlowWilliam L. Furlow More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)66576-5AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We evaluated the efficacy and safety of yohimbine and isoxsuprine or pentoxifylline in the management of vasculogenic erectile dysfunction. Materials and Methods: A total of 20 patients diagnosed with arterial insufficiency and cavernous venous leakage by pharmacological penile duplex scanning underwent nonhormonal oral therapy. A randomized crossover study was performed using 5.4 mg. yohimbine plus 10 mg. isoxsuprine or 400 mg. pentoxifylline 3 times daily. Response to therapy was assessed by a sexual questionnaire and repeat penile duplex ultrasonography. Results: No patient in either phase of the study in either group had a complete response to the oral regimen(s) and there was no improvement in the pre-injection or post-injection cavernous arterial peak systolic flow velocities or resistance indexes. Conclusions: Our study suggests that these oral agents, although well tolerated, were not effective in the management of these patients with mixed vasculogenic erectile dysfunction. References 1 : Oral and transcutaneous pharmacologic agents in the treatment of impotence. Urol. Clin. N. Amer.1988; 15: 87. 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Urology1994; 43: 844. Google Scholar 23 : Local control of human penile helicine arterioles in vitro. J. Urol., part 21989; 141: 544A. abstract 1515. Google Scholar Center for Urological Treatment and Research, Nashville, Tennessee.© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 155Issue 1January 1996Page: 144-146 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.MetricsAuthor Information L. Dean Knoll More articles by this author Ralph C. Benson More articles by this author David L. Bilhartz More articles by this author Peter J. Minich More articles by this author William L. Furlow More articles by this author Expand All Advertisement PDF downloadLoading ...