EVIDENCE FOR PREDOMINANT MEDIATION OF α ₁ -ADRENOCEPTOR IN THE TONUS OF ENTIRE URETHRA OF WOMEN

Abstract

No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Nov 1999EVIDENCE FOR PREDOMINANT MEDIATION OF α1-ADRENOCEPTOR IN THE TONUS OF ENTIRE URETHRA OF WOMEN NAOYUKI TAKI, TAKANOBU TANIGUCHI, KENICHIRO OKADA, NOBUO MORIYAMA, and IKUNOBU MURAMATSU NAOYUKI TAKINAOYUKI TAKI , TAKANOBU TANIGUCHITAKANOBU TANIGUCHI , KENICHIRO OKADAKENICHIRO OKADA , NOBUO MORIYAMANOBUO MORIYAMA , and IKUNOBU MURAMATSUIKUNOBU MURAMATSU View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)68246-8AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We separated the entire length of the isolated human female urethra into seven parts from external urethral meatus to bladder neck and examined regional differences in contractile responses to noradrenaline, clonidine, acetylcholine and KCl. Materials and Methods: The entire urethra was obtained from 9 female patients with a mean age of 72.2 ± 1.8 years. The entire urethra (35 to 42 mm. in length) was transversely cut into seven parts, and the contractile responses to noradrenaline, clonidine, acetylcholine and KCl of these parts were examined. Results: Noradrenaline but not clonidine produced concentration-dependent contraction in all parts, with a peak amplitude in middle to proximal urethra. In contrast, acetylcholine produced contraction only in proximal urethra and bladder neck. The amplitudes of noradrenaline-induced contraction were normalized against those induced by KCl, revealing similarity in patterns between noradrenaline-induced contractions and urethral pressure profile in human female urethra. These contractions to noradrenaline and acetylcholine were competitively inhibited by prazosin (pKB: 8.38 ± 0.10) and atropine (pKB: 8.52 ± 0.43), respectively. Conclusion: These findings suggest that sympathetic innervation helps maintain resting urethral tonus, mainly through α1-adrenoceptors. 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Google Scholar From the Departments of Pharmacology and Urology, School of Medicine, Fukui Medical University, Matsuoka, Fukui, and the Department of Urology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan© 1999 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byBadra S, Andersson K, Dean A, Mourad S and Williams J (2013) Long-Term Structural and Functional Effects of Autologous Muscle Precursor Cell Therapy in a Nonhuman Primate Model of Urinary Sphincter DeficiencyJournal of Urology, VOL. 190, NO. 5, (1938-1945), Online publication date: 1-Nov-2013.Badra S, Andersson K, Dean A, Mourad S and Williams J (2012) A Nonhuman Primate Model of Stable Urinary Sphincter DeficiencyJournal of Urology, VOL. 189, NO. 5, (1967-1974), Online publication date: 1-May-2013.Gratzke C, Jarajapu Y, Christ G, Kaplan J, Williams J, Andersson K and Badlani G (2008) Effects of Long-Term Dietary Soy Treatment on Female Urethral Morphology and Function in Ovariectomized Nonhuman PrimatesJournal of Urology, VOL. 180, NO. 5, (2247-2253), Online publication date: 1-Nov-2008.Banie L, Lin G, Ning H, Wang G, Lue T and Lin C (2008) Effects of Estrogen, Raloxifene and Levormeloxifene on α1A-Adrenergic Receptor ExpressionJournal of Urology, VOL. 180, NO. 5, (2241-2246), Online publication date: 1-Nov-2008.Kessler T, Studer U and Burkhard F (2018) The Effect of Terazosin on Functional Bladder Outlet Obstruction in Women: A Pilot StudyJournal of Urology, VOL. 176, NO. 4, (1487-1492), Online publication date: 1-Oct-2006.ZOUBINA E and SMITH P (2018) Expression Of Estrogen Receptors α And β By Sympathetic Ganglion Neurons Projecting To The Proximal Urethra Of Female RatsJournal of Urology, VOL. 169, NO. 1, (382-385), Online publication date: 1-Jan-2003.MURATA S, TANIGUCHI T, TAKAHASHI M, OKADA K, AKIYAMA K and MURAMATSU I (2018) TISSUE SELECTIVITY OF KMD-3213, AN α1-ADRENOCEPTOR ANTAGONIST, IN HUMAN PROSTATE AND VASCULATUREJournal of Urology, VOL. 164, NO. 2, (578-583), Online publication date: 1-Aug-2000. Volume 162Issue 5November 1999Page: 1829-1832 Advertisement Copyright & Permissions© 1999 by American Urological Association, Inc.Keywordsacetylcholinemuscarinic acetylcholine receptorα1-adrenoceptornoradrenalinehuman female urethraMetricsAuthor Information NAOYUKI TAKI More articles by this author TAKANOBU TANIGUCHI More articles by this author KENICHIRO OKADA More articles by this author NOBUO MORIYAMA More articles by this author IKUNOBU MURAMATSU More articles by this author Expand All Advertisement PDF downloadLoading ...