Metabolism of Fluoroacetate in the Skink (Tiliqua rugosa) and the Rat (Rattus norvegicus)

Abstract

Administration of 100 mg sodium fiuoroacetate (compound 1080) per kilogram body weight to T. rugosa resulted in a 3 ·4-fold increase in plasma citrate levels 48 h after dosing while administration of 3 mg sodium fiuoroacetate per kilogram body weight to R. norvegicus produced a fivefold increase in plasma citrate levels within 4 h. Administration of 300 mg sodium fiuoroacetate per kilogram body weight reduced the oxygen consumption of the skink by between 2·5 and 11 % while in the rat, 2 mg sodium fiuoroacetate per kilogram body weight reduced oxygen consumption by between 28 and 57%.