Phosphodiesterase 8 governs cAMP/PKA-dependent reduction of L-type calcium current in human atrial fibrillation: a novel arrhythmogenic mechanism - Concepedia

Concepedia

Publication | Open Access

Phosphodiesterase 8 governs cAMP/PKA-dependent reduction of L-type calcium current in human atrial fibrillation: a novel arrhythmogenic mechanism

DOI Full Paper Access

42

Citations

52

References

2023

Year

Nefeli Grammatika Pavlidou, Shokoufeh Dobrev, Kira Beneke, Franziska Reinhardt, Simon Pecha, Eric Jacquet, Issam Abu-Taha, Constanze Schmidt, Niels Voigt, Markus Kamler,

European Heart Journal

Abstract

Both PDE8A and PDE8B are expressed in human heart. Upregulation of PDE8B isoforms in cAF reduces ICa,L via direct interaction of PDE8B2 with the Cav1.2α1C subunit. Thus, upregulated PDE8B2 might serve as a novel molecular mechanism of the proarrhythmic reduction of ICa,L in cAF.

References

	Year	Citations

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