Family History and the Risk of Prostatic Carcinoma in a High Risk Group of Urological Patients

Abstract

No AccessJournal of UrologyClinical Urology: Original Article1 Aug 1995Family History and the Risk of Prostatic Carcinoma in a High Risk Group of Urological Patients Armen G.* Aprikian, Michel Bazinet, Mark Plante, Alaa Meshref, Claude Trudel, Samuel Aronson, Mahmoud Nachabe, Francois Peloquin, Jean Dessureault, Steven Narod, Louis Begin, and Mostafa M. Elhilali Armen G.* AprikianArmen G.* Aprikian , Michel BazinetMichel Bazinet , Mark PlanteMark Plante , Alaa MeshrefAlaa Meshref , Claude TrudelClaude Trudel , Samuel AronsonSamuel Aronson , Mahmoud NachabeMahmoud Nachabe , Francois PeloquinFrancois Peloquin , Jean DessureaultJean Dessureault , Steven NarodSteven Narod , Louis BeginLouis Begin , and Mostafa M. ElhilaliMostafa M. Elhilali View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)67063-0AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We examine the association of family history and prostatic carcinoma. Materials and Methods: A total of 2,968 consecutive patients referred for prostate cancer detection responded to a questionnaire and underwent transrectal ultrasound examination with or without biopsy. Results: Of the men 329 (11.1 percent) had a family history of prostate cancer. No differences were observed between groups with and without a family history with respect to mean patient age, serum prostate specific antigen level or biopsy rate. Prostate cancer was detected in 133 of 329 patients (40.4 percent) with a family history and 769 of 2,639 (29.1) with no family history (p less than 0.0001, odds ratio 1.7). No significant differences were observed between cancer patients with or without a family history with respect to mean Gleason score (6.0 versus 6.2), patient age at diagnosis (65.8 versus 66.7) and prostate specific antigen level (16.8 versus 17.1). Conclusions: Patients with a family history of prostate cancer have a greater risk of the disease. In this select group of patients a positive family history was not associated with an earlier age at cancer diagnosis or a different histological grade of tumor. References 1 : Genetic epidemiology of prostate cancer in the Utah Mormon genealogy. Cancer Surv.1982; 1: 47. Google Scholar 2 : Familial factors affecting prostatic cancer risk and plasma sex-steroid levels. Prostate1985; 6: 121. Google Scholar 3 : Family history and the risk of prostate cancer. Prostate1990; 17: 337. Google Scholar 4 : Family aggregation of cancer of the prostate in Quebec: the tip of the iceberg. Prostate1991; 19: 43. Google Scholar 5 : Familial patterns of prostate cancer: a case-control analysis. J. Urol.1991; 146: 1305. Link, Google Scholar 6 : Mendelian inheritance of familial prostate cancer. Proc. Natl. Acad. Sci.1992; 89: 3367. Google Scholar 7 : Prostatic adenocarcinoma in men less than 50 years old: a retrospective review of 151 cases. Cancer1994; 74: 1768. Google Scholar 8 : Prostate specific antigen density: a means of distinguishing benign prostatic hypertrophy and prostate cancer. J. Urol., part 21992; 147: 815. Abstract, Google Scholar 9 : Prospective evaluation of prostate-specific antigen density and systematic biopsies for early detection of prostatic carcinoma. Urology1994; 43: 44. Google Scholar 10 : Hereditary prostate cancer: epidemiological and clinical features. J. Urol.1993; 150: 797. Link, Google Scholar Departments of Surgery, Urology, Pathology and Medicine, McGill University and URO-MED Centre, Montreal, Quebec, Canada.© 1995 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited ByRoemeling S, Roobol M, de Vries S, Gosselaar C, van der Kwast T and Schröder F (2018) Prevalence, Treatment Modalities and Prognosis of Familial Prostate Cancer in a Screened PopulationJournal of Urology, VOL. 175, NO. 4, (1332-1336), Online publication date: 1-Apr-2006.KARAKIEWICZ P, FOULKES W, TANGUAY S, ELHILALI M and APRIKIAN A (2018) Familial Prostate and Breast Cancer in Men Treated with Prostatectomy for Prostate Cancer: A Population based Case-Control StudyJournal of Urology, VOL. 169, NO. 1, (240-244), Online publication date: 1-Jan-2003.Bratt O (2018) Hereditary Prostate Cancer: Clinical AspectsJournal of Urology, VOL. 168, NO. 3, (906-913), Online publication date: 1-Sep-2002.BOVA G, PARTIN A, ISAACS S, CARTER B, BEATY T, ISAACS W and WALSH P (2018) BIOLOGICAL AGGRESSIVENESS OF HEREDITARY PROSTATE CANCER: LONG-TERM EVALUATION FOLLOWING RADICAL PROSTATECTOMYJournal of Urology, VOL. 160, NO. 3 Part 1, (660-663), Online publication date: 1-Sep-1998.Keetch D, Humphrey P, Smith D, Stahl D and Catalona W (2018) Clinical and Pathological Features of Hereditary Prostate CancerJournal of Urology, VOL. 155, NO. 6, (1841-1843), Online publication date: 1-Jun-1996. Volume 154Issue 2August 1995Page: 404-406 Advertisement Copyright & Permissions© 1995 by American Urological Association, Inc.MetricsAuthor Information Armen G.* Aprikian More articles by this author Michel Bazinet More articles by this author Mark Plante More articles by this author Alaa Meshref More articles by this author Claude Trudel More articles by this author Samuel Aronson More articles by this author Mahmoud Nachabe More articles by this author Francois Peloquin More articles by this author Jean Dessureault More articles by this author Steven Narod More articles by this author Louis Begin More articles by this author Mostafa M. Elhilali More articles by this author Expand All Advertisement PDF DownloadLoading ...