Non‐Enzymatic Electrochemical Biosensor for Dopamine Detection Using MoS ₂ /rGO/Ag Nanostructure

Abstract

Abstract Designing an ultra‐sensitive and stable sensor platform for real‐time sensing of dopamine (DA), ascorbic acid (AA) and uric acid (UA) is highly desirable. A simple, green and facile method of synthesis of Ag nanoparticle (AgNP) decorated MoS 2 /rGO nanocomposite for simultaneous electrochemical detection of DA, AA and UA is reported. The unique structural morphology imparts higher electrical conductivity and electrochemical sensitivity to the prepared nanocomposite. The modified electrode material exhibits superior electrocatalytic performance for the detection of DA within a wide linear range of 2.5 to 12.5 μм in presence of interfering electro‐active species AA and UA, with limit of detection (LOD) of 0.009 μм. The sensor exhibits excellent stability with up to 500 repetitive cycles of Cyclic Voltammetry. Chronoamperometry and Electrochemical Impedance reveal sufficient electrochemical stability to find potential diagnostic applications. This nanostructure can emerge as a promising electrode for the detection of DA and UA in human urine samples.