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Replacing the tropolonic methoxyl group of colchicine with methylamino increases tubulin binding affinity with improved therapeutic index and overcomes paclitaxel cross-resistance

Medicinal ChemistryPharmaceutical ScienceBiochemistryTherapeutic IndexMedicineNatural SciencesMechanism Of ActionPharmacotherapyPaclitaxel Cross-resistanceDrug DevelopmentChemical BiologyPharmacologyMethylamino IncreasesPharmaceutical ChemistryDrug DiscoveryDrug Resistance