Synthesis of mono-fluorinated heterocycles with a ring-junction nitrogen atom <i>via</i> Rh(<scp>iii</scp>)-catalyzed CF₃-carbenoid C–H functionalization and defluorinative annulation

Abstract

A Rh-catalyzed two-fold C–F bond cleavage enabled [4 + 2] annulation reaction via CF 3 -carbenoid C–H functionalization of arenes with indoles or various classes of azoles as the directing groups was developed.