Emerging issues on <i>Staphylococcus aureus</i> endocarditis and the role in therapy of daptomycin plus fosfomycin

Abstract

Exploring therapeutic combinations has shown fosfomycin to have a unique mechanism of action and to be the most effective option in preventing the onset of resistance to and optimizing the efficacy of daptomycin, suggesting the synergistic combination of fosfomycin with daptomycin is a useful alternative treatment option for MSSA or MRSA IE.