Molecular Biology of the Cell · 2023 · 25 citations · 44 references
Life SciencesCell BiologyMolecular BiologyApoptosisGene ExpressionGene RegulationApoptosis RegulationCell Cycle ControlCell-cycle RegulationProgrammed Cell DeathStress Signaling PathwaysStress-responsive Gene RegulationCell Fate DecisionsImmunofluorescence AssaysImmunofluorescence ImagingImmunofluorescence StainingLive-cell ImagingNuclear Translocation Of Transcription FactorsNuclear-cytoplasmic ShuttlingTumor Suppression Mechanisms
Both H 2 O 2 and serum starvation activate FOXO transcription factors, but they lead to different FOXO-induced cell outcomes. Here we find a link between the dynamics of FOXO activation and cell fate. H 2 O 2 induces sustained nuclear FOXO, which is linked to cell death, while serum starvation causes pulses of nuclear FOXO and cell-cycle arrest.
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