Inulin impacts tumorigenesis promotion by colibactin-producing Escherichia coli in ApcMin/+ mice

Abstract

Our results suggest that the presence of <i>pks + E. coli</i> influences the outcome of inulin supplementation in CRC and that microbiota-targeted interventions may mitigate this effect. Given the prevalence of <i>pks + E. coli</i> in both healthy and CRC populations and the importance of a fiber-rich diet, inulin supplementation in individuals colonized with <i>pks +</i> bacteria should be considered with caution.