Association of Rare Protein-Truncating DNA Variants in <i>APOB</i> or <i>PCSK9</i> With Low-density Lipoprotein Cholesterol Level and Risk of Coronary Heart Disease - Concepedia

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Association of Rare Protein-Truncating DNA Variants in <i>APOB</i> or <i>PCSK9</i> With Low-density Lipoprotein Cholesterol Level and Risk of Coronary Heart Disease

DOI Full Paper Access

21

Citations

44

References

2023

Year

Jacqueline S. Dron, Aniruddh P. Patel, Yiyi Zhang, Sean J. Jurgens, Dimitri J. Maamari, Minxian Wang, Eric Boerwinkle, Alanna C. Morrison, Paul S. de Vries, Myriam Fornage,

JAMA Cardiology

Abstract

Among 209 537 individuals in this study, 0.4% carried an APOB or PCSK9 PTV that was associated with less exposure to LDL cholesterol and a 49% lower risk of CHD.

References

	Year	Citations

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