Reduction in Junctophilin 2 Expression in Cardiac Nodal Tissue Results in Intracellular Calcium-Driven Increase in Nodal Cell Automaticity

Abstract

Nodal-specific Jph2 knockdown causes increased nodal automaticity through increased Ca²⁺ leak from intracellular stores. Dysregulated intracellular Ca²⁺ underlies nodal arrhythmogenesis in this mouse model.