Effect of transferrin glycation induced by high glucose on HK-2 cells in vitro

Abstract

The degree and sites of Tf glycation were increased <i>in vitro</i> secondary to high-glucose exposure; however, the binding ability of Tf to iron decreased gradually. After HK-2 was stimulated by AGE-Tf <i>in vitro</i>, the apoptosis of cells was increased, antioxidant capacity was decreased, and TfR expression levels were downregulated.