Catalytic Radical‐Polar Crossover Non‐Classical Semipinacol Rearrangements: The Sustainable Approach

Abstract

Semipinacol rearrangement has brought several elegant methods for the rapid synthesis of various complex scaffolds and as a result, has been applied extensively in the total synthesis of natural products. Apart from the classical ways, where transition metal or acids catalyzes the formation of carbocation, the semipinacol rearrangement has seen numerous revolutions and now are being happening in an eco-friendly manner relying on a catalytic radical-polar crossover tool. These catalytic processes are mainly occurring through photocatalysis or electrocatalysis. This review will provide a brief idea of these developments.