ADAR1 Non-Editing Function in Macrophage Activation and Abdominal Aortic Aneurysm

Abstract

Macrophage ADAR1 promotes aneurysm formation in both mouse and human arteries through a novel mechanism, that is, Drosha protein degradation, which inhibits the processing of microRNAs targeting NF-kB signaling and thus elicits macrophage-mediated vascular inflammation in AAA.