Microbiome in paired root apices and periapical lesions and its association with clinical signs in persistent apical periodontitis using next‐generation sequencing

Abstract

The bacterial community composition was similar in the apices and periapical lesions. The microbiome was different in AAP and SAP samples, gram-negative bacteria showing higher relative abundances in SAP cases. An association was observed between amino acid degradation and flagellum assembly pathways, and the development of tenderness to percussion or palpation.