Publication | Closed Access
Absence of <i>N</i>‐acetylaspartate in the human brain: Impact on neurospectroscopy?
95
Citations
18
References
2001
Year
Brain DevelopmentNeurological DisorderNormal ConcentrationNeurochemical BiomarkersBrain ScienceSocial SciencesAbstract N ‐AcetylaspartateNeurobiology Of DiseaseNeurologyBrain PathologyNeuropathologyNeurological FunctionHealth SciencesMolecular NeuroscienceNeuroepidemiologyAbsent NaaFetal NeurodevelopmentNeurological AssessmentNeurodevelopmental DisordersNeurodegenerative DiseasesNeurophysiologyPhysiologyNeuroscienceCentral Nervous System
Abstract N ‐acetylaspartate (NAA) contributes to the most prominent signal in proton magnetic resonance spectroscopy ( 1 H‐MRS) of the adult human brain. We report the absence of NAA in the brain of a 3‐year‐old child with neurodevelopmental retardation and moderately delayed myelination. Since normal concentration of NAA in body fluids is hardly detectable, 1 H‐MRS is a noninvasive technique for identifying neurometabolic diseases with absent NAA. This report puts NAA as a neuronal marker to question. Ann Neurol 2001;49:518–521
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