Prolonged sedation with sevoflurane in comparison to intravenous sedation in critically ill patients – A randomized controlled trial

Abstract

ICU patients sedated with sevoflurane >48 h may return to spontaneous breathing faster, while the quality of sedation is comparable to a propofol-based sedation regime. Sevoflurane might be considered to be safe for long-term sedation in this patient population, while being non-inferior compared to propofol.