Emerging resistance in<i>Staphylococcus epidermidis</i>during dalbavancin exposure: a case report and<i>in vitro</i>analysis of isolates from prosthetic joint infections

Abstract

Exposure to dalbavancin may lead to reduced susceptibility to dalbavancin through either selection of pre-existing subpopulations, epigenetic changes or spontaneous mutations during antibiotic exposure. Source control combined with adequate antibiotic concentrations may be important to prevent emerging reduced susceptibility during dalbavancin treatment.