Identification of single nucleotide polymorphisms by a peptide nucleic acid-based sandwich hybridization assay coupled with toehold-mediated strand displacement reactions

Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide

Peter E. Nielsen, Rolf H. Berg, Ole Buchardt · Science · 1991 · 3.3K citations

Life Sciences, Biomolecular Engineering, Molecular Biology +17

PNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rules

Ole Buchardt, Leif Christensen, Carsten Behrens et al. · Nature · 1993 · 2.1K citations

Life Sciences, Biology, Molecular Biology +11

Stability of peptide nucleic acids in human serum and cellular extracts

Vadim V. Demidov, Vladimir N. Potaman, M.D. Frank-Kamenetskil et al. · Biochemical Pharmacology · 1994 · 741 citations

Life Sciences, Biochemistry, Molecular Biology +11

A genome-wide scalable SNP genotyping assay using microarray technology

Kevin L. Gunderson, Frank J. Steemers, Grace Lee et al. · Nature Genetics · 2005 · 656 citations

Life Sciences, Genetics, Molecular Genetics +11

Genetic Heterogeneity of the Epidermal Growth Factor Receptor in Non–Small Cell Lung Cancer Cell Lines Revealed by a Rapid and Sensitive Detection System, the Peptide Nucleic Acid-Locked Nucleic Acid PCR Clamp

Yoshiaki Nagai, Hitoshi Miyazawa, Huqun et al. · Cancer Research · 2005 · 511 citations

Medicine, Molecular Biology, Oncology +15