Dominant-negative signal transducer and activator of transcription (STAT)3 variants in adult patients: A single center experience

Abstract

Dupilumab can be used safely as a biotherapy for atopic dermatitis in these patients as it can effectively alleviate eczema-related symptoms. Immunologists and dermatologists treating AD-HIES adult patients should be aware of demodicosis as a possible manifestation. DN-<i>STAT3</i> variants in DBD do not hamper STAT3 phosphorylation.