Characteristics of a Soluble Nuclear Antigen Precipitating with Sera of Patients with Systemic Lupus Erythematosus

TLDR

Sera of patients with systemic lupus erythematosus contain antibodies that precipitate soluble tissue components other than DNA. A dominant Sm system reaction was identified, involving a non‑histone, periodate‑sensitive nuclear antigen present in many species’ cells, with antibodies detected by complement fixation and showing high incidence and specificity for systemic lupus erythematosus.

Abstract

Summary Sera of patients with systemic lupus erythematosus were demonstrated to contain precipitating antibodies to soluble tissue components other than DNA. One dominant reaction was observed which was provisionally termed the Sm system. The antigen involved was identified in nuclei of a wide variety of cells from different species. It was associated with protein fractions but was a non-histone substance quite sensitive to periodate treatment. Antibodies to the Sm antigen could also be detected by complement fixation. They showed a high incidence in systemic lupus erythematosus with considerable specificity for the disease.