Publication | Closed Access
Immunity to Sporozoite-Induced Malaria Infection in Mice
85
Citations
0
References
1977
Year
Laboratory ImmunologyAdaptive Immune SystemMalariaImmunologyCellular ImmunologyImmune RegulationImmunologic MechanismInnate ImmunityImmune SystemInflammationCellular BasisSporozoite ChallengeImmunopathologySporozoite-induced Malaria InfectionParasitologyBlcf1 MiceAllergyParasitic ProtozoaImmune SurveillanceT Cell ImmunityHumoral ImmunityImmune FunctionAdaptive ImmunityImmune Cell DevelopmentMedicine
Abstract The cellular basis of immunity to sporozoites was investigated by examining the effect of immunization of T and B cell-deficient C57BL/6N × BALB/c AnN F1 (BLCF1) mice compared to immunocompetent controls. Immunization of T cell-deficient (ATX-BM-ATS) BLCF1 mice with x-irradiated sporozoites did not result in the generation of protective immunity. The same immunization protocols protected all immunocompetent controls. In contrast, B cell-deficient (μ-suppressed) BLCF1 mice were protected by immunization in the majority of cases. The absence of detectable serum circumsporozoite precipitins or sporozoite neutralizing activity in the μ-suppressed mice that resisted a sporozoite challenge suggests a minor role for these humoral factors in protection. These data demonstrate a preeminent role for T cells in the induction of protective immunity in BLCF1 mice against a P. berghei sporozoite infection.