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Synthesis, Assembly, and Secretion of γ Globulin by Mouse Myeloma Cells
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1972
Year
GlycobiologyImmunologyMolecular BiologyCellular PhysiologyMopc 315Tumor BiologyMouse Myeloma CellsSecretory GranulesCell SignalingGlycosylationCellular BiologyIga MonomerCell BiologyNatural SciencesMouse Igaγ GlobulinImmunoglobulin ECellular BiochemistryMedicine
Abstract The synthesis and assembly of mouse IgA has been examined in the Adj-PC 6A cell line and in the MOPC 209B and MOPC 315 tumors. The pathway of assembly of the IgA monomer in these tumors appears to be H + H → H2; H2 + L + L → H2L2; H2L2 + H2L2 → (H2L2)n. Final assembly of the monomers of 6A and 315 into IgA polymers occurs close to the time of secretion.