The Journal of Immunology · 1972 · 12 citations · 0 references
Life SciencesImmunologyMicrobiologyAdaptive ImmunityCellular ImmunologyImmunology Of Infectious DiseasesAntibody CharacterizationAntibody-antigen RecognitionAntigen RecognitionBacterial ImmunologyHumoral Immune ResponsesHumoral ImmunityAntigen-specific Antibody ResponsesBacterial AntibodiesBacterial Endotoxins In SerologyBacterial Lipopolysaccharide RecognitionHumoral Immunity To BacteriaImmunoglobulin Responses
Abstract The antibody response to Salmonella lipopolysaccharides was investigated at the cellular level by means of a hemolytic plaque test combined with inhibition. With these techniques the cross-reactivity of antibodies produced by single cells could be studied. A difference in the ability of mouse strains to produce typical specific antibodies was found. This strain difference resides in the process that recognizes the antigen and is not due to a lack of antibody-producing precursor cells. The role of receptors in the recognition of lipopolysaccharide antigens is discussed.