γG-Antibody to Human Anti-Hemophilic Globulin (Factor VIII)

Abstract

Summary Circulating factor VIII inhibitors from two patients were shown to have many of the characteristics of γG-globulins, namely, resistance to heat and freezing, 7 S sedimentation coefficients, resistance to reduction and alkylation, and a decrease in sedimentation rate with pepsin hydrolysis. Loss of inhibitory activity occurred with the specific precipitation of γG-globulins in one serum. No evidence of complement fixation, agar precipitin reactions or passive cutaneous anaphylaxis activity could be demonstrated.