Ceftriaxone-resistant, multidrug-resistant Neisseria gonorrhoeae with a novel mosaic penA-237.001 gene, France, June 2022

Abstract

We report a ceftriaxone-resistant, multidrug-resistant urogenital gonorrhoea case in a heterosexual woman in France, June 2022. The woman was successfully treated with azithromycin 2 g. She had unprotected sex with her regular partner, who developed urethritis following travel to Vietnam and Switzerland. Whole genome sequencing of the gonococcal isolate (F92) identified MLST ST1901, NG-STAR CC-199, and the novel mosaic <i>penA-237.001</i>, which caused ceftriaxone resistance. <i>penA-237.001</i> is 98.7% identical to <i>penA-60.001</i>, reported in various ceftriaxone-resistant strains, including the internationally spreading FC428 clone.