Biomarkers of tumor-reactive CD4⁺ and CD8⁺ TILs associate with improved prognosis in endometrial cancer.

Abstract

Our results demonstrate that EC are frequently infiltrated by tumor-reactive TILs, and that expression of PD-1^hi and CD39 or PD-1^hi can be used to select and expand CD8⁺ and CD4⁺ tumor-reactive TILs, respectively. In addition, biomarkers preferentially expressed on tumor-reactive TILs, rather than the frequency of CD3⁺, CD8⁺ and CD4⁺ lymphocytes, hold prognostic value suggesting their protective role in antitumor immunity.