Concepedia

Exploring the Potential Mechanism of Artemisinin and Its Derivatives in the Treatment of Osteoporosis Based on Network Pharmacology and Molecular Docking

Yujie Ma, Haixia Liu, Xinyue Lu, Changheng Song, Yin Cheng, Yuhan Wang, Pei Li, Yanjing Chen, Zhiguo Zhang

Computational and Mathematical Methods in Medicine · 2022 · 10 citations · 24 references

DOIFull text

Open access

Abstract

ARS, DHA, ART, ARM and ARE can treat OP through multi-targets and multi pathways, respectively. All five molecules can treat OP by targeting MAPK14 and acting on the IL-17 and prolactin signaling pathways.

References

24

The Prevalence of Osteoporosis in China, a Nationwide, Multicenter DXA Survey

Qiang Zeng, Na Li, Qianqian Wang et al. · Journal of Bone and Mineral Research · 2019 · 349 citations

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Circulating apoptotic bodies maintain mesenchymal stem cell homeostasis and ameliorate osteopenia via transferring multiple cellular factors

Dawei Liu, Xiaoxing Kou, Chider Chen et al. · Cell Research · 2018 · 324 citations · Full text

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Defective autophagy in osteoblasts induces endoplasmic reticulum stress and causes remarkable bone loss

Huixia Li, Danhui Li, Zhengmin Ma et al. · Autophagy · 2018 · 211 citations · Full text

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Amphiregulin contained in NSCLC-exosomes induces osteoclast differentiation through the activation of EGFR pathway

Simona Taverna, Marzia Pucci, Marco Giallombardo et al. · Scientific Reports · 2017 · 153 citations · Full text

Dihydroartemisinin, an Anti-Malaria Drug, Suppresses Estrogen Deficiency-Induced Osteoporosis, Osteoclast Formation, and RANKL-Induced Signaling Pathways

Lin Zhou, Qian Liu, Mingli Yang et al. · Journal of Bone and Mineral Research · 2015 · 103 citations · Full text