The absence of AQP4/TRPV4 complex substantially reduces acute cytotoxic edema following ischemic injury

Abstract

Although simultaneous deletion of AQP4 and TRPV4 did not improve the overall outcome of ischemic brain injury, our data indicate that the interplay between AQP4 and TRPV4 channels plays a critical role during neuronal and non-neuronal swelling in the acute phase of ischemic injury.