Concepedia

Publication | Open Access

Elevated Methionine Flux Drives Pyroptosis Evasion in Persister Cancer Cells

DOIFull Paper Access

32

Citations

49

References

2022

Year

Asmaa El-Kenawi, Anders Berglund, Verónica Estrella, Yonghong Zhang, Min Liu, Ryan M. Putney, Sean Yoder, Joseph Johnson, Joel S. Brown, Robert A. Gatenby
Cancer Research

Abstract

Methionine enables cancer cells to persist by evading pyroptotic osmotic lysis, which leads to genome-wide hypermethylation that allows persisters to gain proliferative advantages.

References

YearCitations

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