Mitophagy and endoplasmic reticulum‐phagy accelerated by a p62 ZZ ligand alleviates paracetamol‐induced hepatotoxicity

Abstract

Our results elucidated that p62-dependent autophagy plays a key role in the removal of cytotoxic materials such as damaged mitochondria in paracetamol-induced hepatotoxicity. Small molecule ligands to p62 may be developed into drugs to treat this pathological condition.