Natural and Pseudonatural Lindenane Heterodimers from <i>Sarcandra glabra</i> by Molecular Networking

Abstract

Sarglaoxolane A (<b>1</b>), the first lindenane-normonoterpene heterodimer fused by tetrahydrofuran, was discovered in <i>Sarcandra glabra</i> guided by the first proposed single-node-based molecular networking approach. Moreover, two pseudonatural derivatives (<b>2</b> and <b>3</b>) with an oxa-difuranofurone moiety were transformed from <b>1</b> and confirmed by X-ray diffraction, and also proven to exist in the plant extract. A combination of molecular networking and biomimetic transformation can significantly promote the discovery and structural elucidation of novel natural products.