Disruption of <scp>Mitochondrial‐associated ER</scp> membranes by <scp>HIV</scp>‐1 tat protein contributes to premature brain aging

Abstract

These results suggest that Tat disrupts the MAM, through the induction of PTPIP51 phosphorylation, leading to ROS accumulation, mitochondrial stress, and altered movement. Hence, we concluded that interfering in the MAM-associated cellular pathways contributes to spatial memory impairment and premature brain aging often observed in HIV-1-infected patients.