Highlighting the Compositional Changes of the Sm2O3/MgO-Containing Cellulose Acetate Films for Wound Dressings

Abstract

The development of wound dressing materials with appropriate specifications is still a challenge to overcome the current limitations of conventional medical bandages. In this regard, simple and fast methods are highly recommended, such as film casting. In addition, deliverable nanoparticles that can act to accelerate wound integration, such as samarium oxide (Sm₂O₃) and magnesium oxide (MgO), might represent a potential design with a novel compositional combination. In the present research, the casted film of cellulose acetate (CA) was mixed with different ratios of metal oxides, such as samarium oxide (Sm₂O₃) and magnesium oxide (MgO). The tests used for the film examination were X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). The SEM graphs of CA films represent the surface morphology of Sm₂O₃@CA, MgO@CA, and Sm₂O₃/MgO/GO@CA. It was found that the scaffolds' surface contained a high porosity ratio with diameters of 1.5-5 µm. On the other hand, the measurement of contact angle exhibits a variable trend starting from 27° to 29° for pristine CA and Sm₂O₃/MgO/GO@CA. The cell viability test exhibits a noticeable increase in cell growth with a decrease in the concentration. In addition, the IC₅₀ was determined at 6 mg/mL, while the concentration of scaffolds of 20 mg/mL caused cellular growth to be around 106%.